Publications

Development of pluripotent stem cells for vascular therapy

An emerging therapeutic approach is cell therapy to enhance angiogenesis and tissue survival. Small clinical trials of adult progenitor cell therapies have generated promising results, although large randomized clinical trials using well-defined cells have not been performed. Intriguing pre-clinical studies have been performed using vascular cells derived from human…

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Safety of intracranial injection of stem cells

[The method of delivery of stem cells is a major factor to consider in the design of clinical trials of cell therapy. Different methods of delivery will be associated with different risks to the patient, and may also be associated with different potential for benefit. Current approaches are partly informed by the routes selected for study in animal models of focal ischaemia and CNS transplantation, but there has …

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How do stem cells repair brain injury?

The development of a neural stem cell (NSC) treatment for ischemic brain injury would be of great benefit. This review focuses on recent advances in knowledge and practices toward the development of a successful NSC therapy for patients who have experienced stroke. The data supporting potential mechanisms by which somatic stem cells orchestrate neuroprotection, neurogenesis and vascularization, leading to pronounced functional improvements in stroke-induced deficits are critically reviewed. A model is proposed in…

Read more on Stem cell treatment of ischemic brain injury, at NCBI

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 Human neural stem cell derived neurons fire action potentials in a dish

Neural stem cells (NSCs) are powerful research tools for the design and discovery of new approaches to neurodegenerative disease. Overexpression of the myc family transcription factors in human primary cells from developing cortex and mesencephalon has produced two stable multipotential NSC lines…

Read more on the neuronal physiological responsiveness in two human neural stem cell lines, at NCBI

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 Regulation of growth factor receptors by glycolipids

Since their discovery in the 1940s, gangliosides have been associated with a number of biological processes, such as growth, differentiation, and toxin uptake. Hypotheses about regulation of these processes by gangliosides are based on indirect observations and lack a clear definition of their mechanisms within the cell. The first insights were provided when a reduction in cell proliferation…

Read more on receptor regulation, at NCBI…

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